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An enzyme that protects the brain from Alzheimer's disease has been discovered

 An enzyme that protects the brain from Alzheimer's disease has been discovered
Researchers in the field of biomedicine from Indiana University have found the evidence that an enzyme known as NMNAT2, can protect the brain from the negative influence of some degenerative diseases, including Alzheimer's disease.


According to Medical Xpress, the results of the research were published in the eve of the journal PLOS Biology. The enzyme is derived NMNAT2 human gene of the same name and, in contrast to other human genes, is located in the cytoplasm - mainly in the human brain. "The research showed that NMNAT2 is key to support neurons, defend them in the aging process of the body from stress and attack mutant proteins that have disrupted protein folding," - said Professor Indiana University Hui-Chen Liu.
According to scientists, many neurodegenerative diseases are caused by the accumulation of proteins in the brain with the so-called proteopathy. This distortion of the structure of a protein, leading to abnormal accumulation and its toxic effects on the body. "Plaques" There are a kind. NMNAT2 can "calculate" and such proteins to prevent or eliminate them due to malfunctions of the brain.
It's not only about Alzheimer's disease but also about Parkinson's disease, Huntington's and Lou Gehrig's disease (amyotrophic lateral sclerosis). In NMNAT2 research, since 1997, was attended by more than 500 elderly patients, whose brain has been studied in the last days of their lives. Patients with cognitive disorders reduce vector physicians have found higher levels of NMNAT2, than in other subjects. Later, research was conducted on laboratory mice with high levels of toxic tau proteins in the body - raising NMNAT2 levels in the hippocampus reduced levels of these proteins.

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