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The genetic code of red blood cells has been "hacked" using bust method

The genetic code of red blood cells has been "hacked" using bust method
Researchers from Lund University (Sweden) all have deciphered the genetic keys of red blood cells. The opening will create red blood cells in the laboratory.
In experiments on mice, scientists introduced via retroviral combination of more than 60 genes in the DNA of skin cells. The method of sorting fibroblasts managed to turn in erythroid precursors, virtually identical red blood cells. The transformation, which lasts eight days, involves the use of a minimum set of the following genes: GATA1, LMO2, Tal1, c-Myc (GTLM).
In tests on people this model has been less effective. So, enough experts successfully managed to suppress reprogramming the fibroblast-specific genes. It is assumed that a problem could arise due to insufficient expression of c-Myc gene, whose main function is to regulate the transcription of most other genes.
However, according to lead researh author Sandra Capeller, this is the first convert skin cells into red blood cells. The results have a great importance both in theoretical and practical aspects. In particular, the decrypted code gives scientists a better understanding of the mechanism of formation of red blood cells. However, it opens up possibilities for the reproduction of cells for the donor or for other purposes.
The technology can be very useful for anemia - a condition which is characterized by a decrease in hemoglobin concentrations and which  cosists of red blood cells. Such patients need regular blood transfusion, which ultimately causes an intolerance to someone else's blood. Creating their own red blood cells from fibroblasts can facilitate for disease.

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